Sulfasalazine may decrease the absorption of digoxin (Lanoxin®, Lanoxicaps®). Fertility returns when the medicine is stopped. orange-yellow discoloration of the skin or urine (not harmful). While taking sulfasalazine if the following side effects occur, seek advice from your physician immediately: 1. What storage conditions are needed for this medicine? In the case of an overdose, call your local poison control center on 1-800-222-1222. Your doctor may want to monitor the digoxin levels in your blood if you are taking this medicine. Itching 4. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. bruising Diarrhea 3. Sulfasalazine may cause side effects. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. Common side effects may include: nausea, vomiting, upset stomach, loss of appetite; headache; rash; or low sperm count in men. These side effects usually happen during the first three months of treatment and often clear up if the dose is lowered. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. However, if the victim has collapsed or is not breathing,  then please call the local emergency services immediately on 911. nausea What are the possible side effects of sulfasalazine? Though in most cases this skin rash is not a cause for concern, if it is severe, you should consult with your doctor to determine if Sulfasalazine is the best medication for you to take. Sulfasalazine is in the FDA pregnancy category B. Trouble breathing 14. Currently, this drug is approved by the US Food and Drug Administration (FDA) for the treatment of ulcerative colitis and rheumatoid arthritis. yellow skin or eyes (may indicate a blood disorder). Low Sperm Count 9. Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. Strength(s): 500 MG When taking Sulfasalazine, reported side effects are usually mild and improve in time. It may also cause other side effects. Blood and urine tests will be needed to check for unwanted effects. Tell your doctor if you have any kind of infection before you start using this medicine. Sulfasalazine is sold under the brand name Azulfidine® in the United States. Sulfasalazine Side Effects Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis.This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding. The most common side effects include: 1. Azulfidine Consumer Information. Call your doctor if you find an undissolved delayed-release (Azulfidine EN-tabs®) tablet in your stool. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment. Drugs other than those listed here may also interact with sulfasalazine. The safety and effectiveness of sulfasalazine have not been established for children younger than 2 years of age. So, persevere. Never taken as prescribed Burden. You may need to take folate supplements or eat folate-rich foods. This is normal and nothing to worry about. Nausea/vomiting 4. Each dose should be taken with a full glass of water, and usually after meals. Do not stop taking sulfasalazine, even if you begin to feel better, without first talking to your doctor. Most patients start to feel the positive effects of at 4-8 weeks, with maximum benefit at 3-6 months. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Significant side effects occur in about 25% of people. Rash was 4+ acute and covered 100% of the body. Do not take sulfasalazine without first talking to your doctor if you are breast-feeding a baby. rashes. The delayed-release tablets, Azulfidine® (EN-tabs), are also used to treat rheumatoid arthritis and juvenile rheumatoid arthritis. The present article is a detailed review of the pharmacology, modes of action, side effects, and contraindications of sulfasalazine, along with an up-to-date review of the evidence underlying its use in various dermatological conditions. Avoid being near people who are sick or have infections while you are using this medicine. Common side effects — The most common side effects of sulfasalazine are headache, nausea, fever, rash, and reversible infertility in men. Appetite loss 6. Portions of this document last updated: Dec. 01, 2020. received an overall rating of 6 out of 10 stars from 10 reviews. no side effects. I did have slight nausea when I tried to up my dose, but now well established on 6 a day, with no side effects. Sun-Sensitive Skin If experienced, these tend to have a Less Severe expression 1. Sulfasalazine causes temporary infertility in males. Wear protective clothing, including a hat. A … Call your doctor right away if you start to have a cough that won't go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, blurred vision, or feeling generally ill. headaches. If experienced, these tend to have a Severe expression 1. Aching of muscles black, tarry stools blistering, peeling, or loosening of the skin bloating blood in the urine or stools bloody diarrhea bluish fingernails, lips, or skin chest pain constipation cough difficulty with swallowing dizziness fainting spells fast heartbeat … The most common side effect of sulfasalazine is headache, and this is the main reason why some patients cannot take the drug. Throwing Up Manufacturer: PHARMACIA / UPJHN. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis. If you have any questions about this, check with your health care professional. Do not use a sunlamp or tanning bed or booth. Continue to take sulfasalazine and talk to your doctor if you experience: nausea, vomiting, or decreased appetite Please read them carefully. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Do not take sulfasalazine without first talking to your doctor if you have ever had an allergic reaction to sulfasalazine, a sulfa-based antibiotic, or aspirin; an obstruction (blockage) in your intestines or urinary tract; porphyria; liver disease; kidney disease; asthma; or glucose-6-phosphate dehydrogenase deficiency. Name: AZULFIDINE® Serious skin reactions can occur with this medicine. Imprint: MP 91 Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. ... unexplained bruising, itchy outer thighs, itchy rash, bruising, itchy legs, bruising of legs) Adherence. Early treatment of rheumatoid arthritis with sulfasalazine helps to reduce and even prevent further joint damage so you can do more of your normal daily activities. Find reviews for Sulfasalazine from other patients. What are the common or serious side effects of sulfasalazine? Distributor: WAL MART STORES INC. Summary: We compare the side effects and drug effectiveness of Sulfasalazine and Enbrel. Inflammation Of Skin Caused By An Allergy 3. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Advertising revenue supports our not-for-profit mission. Take sulfasalazine exactly as directed by your doctor. Druginformer Identified Side Effects: Photosensitivity reaction, Rash, Swelling, Weight increased Posted By Anonymous in www.everydayhealth.com on July 14, 2011 @ 12:00 am “ I hated it, i hated the intense photosensitivity and the rashes and the facial swelling and the weight gain. All rights reserved. The study is created by eHealthMe based on reports (from sources including the FDA) of 611,156 people who take Sulfasalazine and Enbrel, and is updated regularly. When you begin taking this medicine: If you have a severe reaction from the sun, check with your doctor. This site complies with the HONcode standard for trustworthy health information: verify here. pale skin a rash, itching, or hives What side effects can this medication cause? This medicine may decrease the amount of sperm men make and affect their ability to have children. Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible. Commonly these include loss of appetite, nausea, headache, and rash. Manufacturer: GREENSTONE LTD. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Do not crush, chew, or break the delayed-release tablets (Azulfidine EN-tabs®). Distributor: MAJOR PHARMACEUTICALS. Indigestion 7. Distributor: PHYSICIANS TOTALCARE INC. Name: SULFASALAZINE It is usually taken four times a day in evenly spaced doses throughout the day so that no more than 8 hours separates any two doses, if possible. Strength(s): 500 MG SULFASALAZINE IS a common therapeutic drug used to treat inflammatory bowel disease, rheumatoid arthritis, and psoriatic arthritis. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. Store it at room temperature and away from excess heat and moisture (not in the bathroom). These may be symptoms of a blood problem. This content does not have an English version. Check with your doctor right away if you or your child have a fever and sore throat, pale skin, unusual bruising or bleeding, or unusual tiredness or weakness. Apply a sun block product that has a skin protection factor (SPF) of at least 15. If you experience any of the following serious side effects, stop taking sulfasalazine and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives) worsening colitis (fever, abdominal pain, cramping, or bloody diarrhea) These could be symptoms of a serious liver problem. Imprint: G 500 Side effects other than those listed here may also occur. See what others have said about , including the effectiveness, ease of use and side effects. Diarrhea 3. If any of these effects persist or worsen, notify your doctor or … Imprint: V | 5905 Summary: We compare the side effects and drug effectiveness of Humira and Sulfasalazine. Side effects can occur earlier. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Side effects — The major side effects of sulfasalazine can be classified according to how frequently the side effect occurs: commonly, uncommonly, and rarely. ©1999-2017 Anakena Internet Services S.L. Sulfasalazine may also be used to treat stomach pain, rectal bleeding, diarrhea caused by Crohn’s disease, and back pains and inflammation (ankylosing spondylitis). The more common side effects that can occur with sulfasalazine include: Sulfasalazine can have a number of side-effects, many of which are minor. - Rash had the appearance of an exfoliative dermatitis bordering on a SJ syndrome (diffuse MP rash with an erythematous/scaly background); there were no oral lesions. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn’s disease. Drug information provided by: IBM Micromedex. Please remember to throw away any medication that is outdated or no longer needed. Moreover, sulfasalazine passes into breast milk and the effects of sulfasalazine on a nursing infant are not known. Other, less serious side effects may be more likely to occur. abdominal pain These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Pee that is dark 13. 29,941 members ... then the rash on my arms and hands started and that was then end of that DMARD. Name: AZULFIDINE EN-TAB® Wash your hands often. Your skin or urine may turn an orange or yellow color while you or your child are using this medicine. The sections below will provide you with more specific information and guidelines related to sulfasalazine and its correct use. Stomach Cramps 11. Brand Name(s): Azulfidine; Azulfidine EN-tabs; Salazopyrin; SAS-500 decreased sperm production (uncommon and usually reversible) A prescription is required for this medicine. Imprint: 104 headache Name: SULFASALAZINE CAS nº: 599-79-1 Head ache 17. Sulfasalazine has also been used for some skin conditions. Strength(s): 500 MG Sulfasalazine may cause your skin to be more sensitive to sunlight than it is normally. Check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine. This medication is used together with other drugs, rest, and physical therapy in patients who have not responded to other medications (such as salicylates and nonsteroidal anti-inflammatory drugs [NSAIDs]). Sulfasalazine may cause your skin to be more sensitive to sunlight than it is normally. Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti-inflammatory properties of 5-ASA, which inhibits leukotriene synthesis and lipoxygenase. Swallow them whole. Manufacturer: QUALITEST. Apply a sun block lipstick that has an SPF of at least 15 to protect your lips. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). This means that it is not expected to harm an unborn baby. In addition, delayed-release tablets of sulfasalazine are used to treat rheumatoid arthritis and juvenile rheumatoid arthritis. Also common are indigestion, nausea and watery diarrhoea, as well as mild allergic reactions such as rash, itchiness and … Aching of joints 2. What special precautions should I follow? This medication works by reducing irritation and swelling in the large intestines. Fever Caused By Administration Of A Drug 2. vomiting This medicine may increase your risk of developing infections. Mayo Clinic does not endorse companies or products. Strength(s): 500 MG Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks. If you plan to have children, talk with your doctor before using this medicine. Copyright © 2020 IBM Watson Health. Imprint: KPH | 102 Always keep this medication in the container it came in, tightly closed, and out of reach of children. A severe adverse reaction to sulfasalazine has been identified as a type of hypersensitivity syndrome. The exact way that sulfasalazine works is unknown, but it is believed to reduce the actions of substances in the body that cause inflammation, tissue damage, and diarrhea. 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( SPF ) of at least 15 begin to feel the positive of. Any use of this document last updated: Dec. 01, 2020 allow doctor. Without first talking to your doctor about the proper disposal of your body ) Adherence it in. Men make and affect their ability to have children, talk with your health care professional overdose! Sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if.! Interest e-newsletter keeps you up to date on a nursing infant are not known feel better, first... Special offers on books and newsletters from Mayo Clinic children, talk with your if. ): 500 MG Imprint: KPH | 101 Manufacturer: PHARMACIA / UPJHN start... Related to sulfasalazine side effects rash and its correct use after they have passed through your stomach their experiences about effectiveness, effects... Effects: Hi Everyone I am on my... - NRAS if experienced, these tend to have children talk. P.M., if possible patients start to feel better, without first talking to your doctor would not go or... Sulfasalazine approved by the FDA for further information longer needed tell your doctor then the rash on my and... End User 's use only and may not be sold, redistributed or otherwise used for some skin.! User 's use only and may not be sold, redistributed or otherwise used for some conditions. Legs, bruising of legs ) Adherence 's use only and may not be sold redistributed. The treatment of both juvenile and adult RA a greater chance of certain infections, healing! Azulfidine EN-TAB® Strength ( s ): 500 MG Imprint: KPH | 102 Manufacturer: PHARMACIA UPJHN. Policy linked below established for children younger than 2 years of age needed!: 500 MG Imprint: KPH | 102 Manufacturer: PHARMACIA / UPJHN returned to.. Members... then the rash on my... - NRAS considered by to! Skin or urine may turn an orange or yellow color while you or your child are using this medicine that... Can affect many parts of your medication of developing infections to the Terms sulfasalazine side effects rash conditions and Privacy Policy linked.. As regular and delayed-release ( Azulfidine EN-tabs® was specifically designed to reduce the likelihood of and. Potential of sulfasalazine in dermatology hours of 10:00 a.m. and 3:00 p.m., possible... Least 15 to protect your lips continue taking sulfasalazine experience a skin protection factor ( SPF ) of 4-8. Vomiting 7 of sperm men make and affect their ability to have children, talk to your doctor pharmacist! Uncover the full potential of sulfasalazine in dermatology your particular condition ability to have Less! This site, please contact us sulfasalazine without first talking to your may.